Abstract | BACKGROUND: RESULTS: CONCLUSIONS: PC12 cells expressing the beta PDGF receptor extend neurites in response to PDGF in the absence of signalling through PI 3-kinase, RasGAP, and PLC-gamma 1. This contrasts with the requirements for mitogenesis for epithelial and fibroblast cell lines, in which the association of PI 3-kinase with the beta PDGF receptor is essential. This receptor protein-tyrosine kinase therefore phosphorylates and activates a similar set of intracellular signalling molecules in the context of both mitogenesis and differentiation, but the importance of particular pathways for each phenotypic response is distinct.
|
Authors | M L Vetter, J M Bishop |
Journal | Current biology : CB
(Curr Biol)
Vol. 5
Issue 2
Pg. 168-78
(Feb 01 1995)
ISSN: 0960-9822 [Print] England |
PMID | 7743180
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- GTPase-Activating Proteins
- Intracellular Signaling Peptides and Proteins
- Isoenzymes
- Platelet-Derived Growth Factor
- Proteins
- ras GTPase-Activating Proteins
- Protein Kinases
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Receptors, Platelet-Derived Growth Factor
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases
- Ptpn11 protein, rat
- Ptpn6 protein, rat
- Type C Phospholipases
- Phospholipase C gamma
|
Topics |
- Animals
- Cell Division
(genetics)
- Enzyme Activation
- GTPase-Activating Proteins
- Intracellular Signaling Peptides and Proteins
- Isoenzymes
(metabolism)
- Mutation
- Neurites
- PC12 Cells
- Phosphatidylinositol 3-Kinases
- Phospholipase C gamma
- Phosphotransferases (Alcohol Group Acceptor)
(metabolism)
- Platelet-Derived Growth Factor
(pharmacology)
- Protein Kinases
(metabolism)
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases
(metabolism)
- Proteins
(metabolism)
- Rats
- Receptors, Platelet-Derived Growth Factor
(genetics, physiology)
- Signal Transduction
- Type C Phospholipases
(metabolism)
- ras GTPase-Activating Proteins
|