Abstract | AIMS: METHODS: The basal tear turnover of 20 patients with open angle glaucoma or ocular hypertension was measured by computerised objective fluorophotometry when using topical timolol preserved with BAC and 2 weeks after changing to topical timolol containing no preservative. Evaluation of the precorneal tear film was done by measuring the break up time (BUT) before and 2 weeks after changing medication. RESULTS: The tear turnover of the patients before the change was 32% lower than that of healthy controls (mean tear turnover values (SD) (%/min): 10.7 (3.0) and 15.6 (5.4), respectively, p < 0.0001). A mean increase of 28% (47%) in the individual tear turnover values was found after the change to the preservative-free timolol (p = 0.04). The BUT values before the change of medication did not differ significantly from those after the change (p = 0.5) but both values were significantly lower than the values of healthy controls (p = 0.009 and p = 0.003, respectively). CONCLUSION:
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Authors | E V Kuppens, C A de Jong, T R Stolwijk, R J de Keizer, J A van Best |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 79
Issue 4
Pg. 339-42
(Apr 1995)
ISSN: 0007-1161 [Print] England |
PMID | 7742279
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzalkonium Compounds
- Preservatives, Pharmaceutical
- Timolol
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Topics |
- Benzalkonium Compounds
(pharmacology)
- Fluorophotometry
- Glaucoma, Open-Angle
(drug therapy, physiopathology)
- Humans
- Middle Aged
- Ocular Hypertension
(physiopathology)
- Preservatives, Pharmaceutical
- Secretory Rate
(drug effects)
- Tears
(drug effects, metabolism)
- Timolol
(pharmacology, therapeutic use)
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