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Role of nitric oxide in the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat.

AbstractBACKGROUND:
Nitric oxide (NO) has been shown to be involved in mediating nociceptive information transmission in the spinal cord. It is known that the N-methyl-D-aspartate receptor plays an important role in the development of the spinal facilitation evoked by a protracted small afferent input and that this effect is mediated at least in part by NO. Recently, it has been found that N-methyl-D-aspartate receptor-mediated spinal facilitation is crucial in the development of thermal hyperesthesia evoked by a nerve constriction injury. In the current study, we investigated the role of NO in the development of thermal hyperesthesia after a nerve constriction injury.
METHODS:
The Bennett and Xie model (four loose chromic gut ligations around the rat sciatic nerve) was used to examine the development of thermal hyperesthesia. An NO synthase inhibitor (N omega-nitro-L-arginine or N omega-nitro-L-arginine methyl ester hydrochloride), rat hemoglobin, or L-arginine was administered intrathecally 10 min before the nerve injury (pretreatment study) or 15 min after the nerve injury (posttreatment study).
RESULTS:
Pretreatment but not posttreatment administration of NO synthase inhibitor significantly delayed the development of thermal hyperesthesia. The effect of NO synthase inhibitor was reversed by the coadministration of L-arginine but not by the coadministration of D-arginine. Pretreatment with rat hemoglobin also delayed the development of thermal hyperesthesia. L-Arginine itself had no effect on the development of thermal hyperesthesia.
CONCLUSIONS:
NO may play an important role in the development of N-methyl-D-aspartate receptor-mediated spinal facilitation after a nerve constriction injury.
AuthorsT Yamamoto, N Shimoyama
JournalAnesthesiology (Anesthesiology) Vol. 82 Issue 5 Pg. 1266-73 (May 1995) ISSN: 0003-3022 [Print] UNITED STATES
PMID7741302 (Publication Type: Journal Article)
Chemical References
  • Receptors, N-Methyl-D-Aspartate
  • Nitroarginine
  • Nitric Oxide
  • Arginine
  • NG-Nitroarginine Methyl Ester
Topics
  • Animals
  • Arginine (analogs & derivatives, pharmacology)
  • Constriction
  • Hot Temperature
  • Hyperesthesia (etiology)
  • Male
  • NG-Nitroarginine Methyl Ester
  • Nitric Oxide (physiology)
  • Nitroarginine
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate (physiology)
  • Sciatic Nerve (injuries)

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