Abstract |
The subjective impression among clinicians that the use of Rifater was causing delayed sputum conversion and increased drug resistance was tested in a prospective study. Adults in the Cape Town municipal area with a first episode of pulmonary tuberculosis were treated either with Rifater or a regimen consisting of isoniazid, rifampicin, pyrazinamide and ethambutol. All patients who took the treatment as prescribed (67 Rifater, 39 the 4- drug regimen) converted to a negative sputum culture by the time 90 doses had been taken. The rates of inadequate compliance and of side-effects were similar in the two groups. Drug sensitivity testing of bacteria cultured from pre-treatment sputum specimens revealed an overall primary resistance rate of 4.84% in the population studied, sufficiently low to preclude any necessity for routine pre-treatment drug sensitivity testing.
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Authors | M F Macnab, P D Bohmer, J R Seager |
Journal | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
(S Afr Med J)
Vol. 84
Issue 6
Pg. 325-8
(Jun 1994)
ISSN: 0256-9574 [Print] South Africa |
PMID | 7740377
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Antitubercular Agents
- Drug Combinations
- isoniazid, pyrazinamide, rifampin drug combination
- Pyrazinamide
- Ethambutol
- Isoniazid
- Rifampin
- Streptomycin
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Topics |
- Antitubercular Agents
(therapeutic use)
- Drug Combinations
- Drug Resistance, Microbial
- Ethambutol
(adverse effects, therapeutic use)
- Humans
- Isoniazid
(adverse effects, therapeutic use)
- Patient Compliance
- Prospective Studies
- Pyrazinamide
(adverse effects, therapeutic use)
- Rifampin
(adverse effects, therapeutic use)
- Sputum
(microbiology)
- Streptomycin
(adverse effects, therapeutic use)
- Tuberculosis
(drug therapy)
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