[Comparative study of cefixime versus amoxicillin-clavulanic acid combination in the oral treatment of urinary tract infections in children].

Abstract

BACKGROUND:

Acute febrile infections suggestive of pyelonephritis require treatment by broad-spectrum antibiotics capable of reaching significant tissue levels. This study compares efficacy and safety of cefixime with amoxycillin + clavulanic acid in urinary tract infections.

POPULATION AND METHODS:

Fifty seven children aged 5 months to 14 years treated for urinary tract infection in ten pediatric centres for a period of 10 months had been randomly included in the study. Thirty (22 girls and eight boys) were given cefixime and 27 (24 girls and three boys) amoxycillin-clavulanate. Efficacy was evaluated in only 36 patients whose bacteria were susceptible to both antibiotics (26 pyelonephritis and ten cystitis).

RESULTS:

Sixteen patients out of the 19 given cefixime recovered vs. 14 out of the 17 given amoxycillin-clavulanate with no significant difference between both groups. Bacteria were more often susceptible to cefixime (100% of cases) than to amoxycillin-clavulanate (69%) (p < or = 0.0001). Safety was good and comparable in both groups.

CONCLUSION:

Cefixime given per os seems effective and safe in treating urinary tract infections. These results have to be confirmed by further studies.

• Authors: P François, J Croizé, C Bost, K Wollschlager
• Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (Arch Pediatr) Vol. 2 Issue 2 Pg. 136-42 (Feb 1995) ISSN: 0929-693X [Print] France
• Vernacular Title: Etude comparant le céfixime à l'association amoxicilline-acide clavulanique dans le traitement par voie orale des infections urinaires de l'enfant.
• PMID: 7735445 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Clavulanic Acids
• Drug Combinations
• Amoxicillin
• Cefixime
• Cefotaxime

Topics

• Administration, Oral
• Adolescent
• Amoxicillin (administration & dosage, therapeutic use)
• Anti-Bacterial Agents (therapeutic use)
• Cefixime
• Cefotaxime (analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Clavulanic Acids (administration & dosage, therapeutic use)
• Drug Combinations
• Drug Tolerance
• Female
• Humans
• Infant
• Male
• Prospective Studies
• Urinary Tract Infections (drug therapy)