[A case of mixed connective tissue disease associated with gastric cancer and cancer of the uterine cervix].

Abstract

We report here a very rare case of MCTD complicating double cancer. A 43-year-old woman with suspected MCTD was admitted because of high fever and lymphadenopathy. The laboratory findings indicated high titers of speckled ANA, anti-RNP, DNA and Scl-70, but anti-Sm. SS-A and SS-B was not detected. Chest CT and Spirogram revealed lung fibrosis, restrictive ventilatory impairment, and decreased diffusion capacity. Biopsy specimen by gastric fiberscope s screening indicated II c advanced type of poorly differentiated adenocarcinoma. After subtotal gastrectomy, she had high fever, pleuritis, leukopenia, butterfly erythema and hypoxemia, which were improved by 30 mg/day of oral prednisolone. One year after from the last operation, she had contact bleeding, and squamous cell carcinoma of the uterine cervix was diagnosed. She had Raynaud's phenomenon 6 months after from hysterectomy.

• Authors: M Katayama, I Tanaka, Y Hosako, N Hama, T Yamada, S Inada, M Goto
• Journal: Ryumachi. [Rheumatism] (Ryumachi) Vol. 35 Issue 1 Pg. 85-9 (Feb 1995) ISSN: 0300-9157 [Print] Japan
• PMID: 7732496 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Topics

• Adenocarcinoma (complications)
• Adult
• Carcinoma, Squamous Cell (complications)
• Female
• Humans
• Mixed Connective Tissue Disease (complications)
• Neoplasms, Multiple Primary
• Stomach Neoplasms (complications)
• Uterine Cervical Neoplasms (complications)