[Autoimmune thrombocytopenia in pregnant women: diagnosis, treatment and prevention of complications in children].

Abstract

9 pregnancies (in 6 women) complicated by autoimmune thrombocytopenia were studied. Corticosteroids and/or azathioprine and/or intravenous immunoglobulins (IgG i.v.) were administered to 5 women during pregnancy. 1 complete remission (CR) was achieved after 3 mo. of treatment by corticosteroids and azathioprine. In peripartum period the treatment was administered in 7 cases (corticosteroids, IgG i.v., platelet transfusion). There were no haemorrhagic complications during peripartum period (8 vaginal delivery, 1 cesarean section). In 3 of 5 examined cases IgG antiplatelet antibody was detected. Study group was to small to define the correlation between level of antiplatelet antibodies and neonatal thrombocytopenia. 10 infants were born. 4 infants (including siblings) were found to have normal platelet counts immediately after delivery. They mothers were treated by IgG i.v. in 2 cases and 1 women in CR at the time of delivery. 4 infants were thrombocytopenic but required no treatment. Duration time of thrombocytopenia was 1 to 4 weeks. In these cases mothers were treated only by corticosteroids or had no therapy.

• Authors: I Kopec, M Słomkowski, W Puzyna, K Maslanka, S Maj
• Journal: Ginekologia polska (Ginekol Pol) Vol. 65 Issue 10 Pg. 553-8 (Oct 1994) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Autoimmunologiczna małopłytkowosc u kobiet w ciazy: rozpoznawanie, leczenie, zapobieganie powikłaniom u dzieci.
• PMID: 7729714 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenal Cortex Hormones
• Immunoglobulins, Intravenous
• Azathioprine

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Autoimmune Diseases (complications, diagnosis, therapy)
• Azathioprine (therapeutic use)
• Female
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Infant, Newborn
• Pregnancy
• Pregnancy Complications, Hematologic (diagnosis, therapy)
• Pregnancy Outcome
• Remission Induction
• Thrombocytopenia (complications, diagnosis, therapy)
• Treatment Outcome