Abstract | PURPOSE: METHODS: The authors reviewed the records of patients with OCP, Stevens-Johnson syndrome, or toxic epidermal necrolysis seen between 1976 and 1992. Patients who underwent PK were examined for the purpose of this study. Initial and final visual acuity, indications for PK, surgical procedure, postoperative therapy, complications, total number of repeat PKs, length of follow-up, and the final outcome were recorded. RESULTS: Thirty-two PKs were performed in 16 eyes of 13 patients with advanced OCP (6 patients), OCP as a sequela of Stevens-Johnson syndrome (2 patients), Stevens-Johnson syndrome (3 patients), and toxic epidermal necrolysis (2 patients). The indications for the first PK were corneal perforation in six eyes (37.5%) and extensive corneal scarring in ten eyes (62.5%). Preoperative visual acuity was counting fingers in five eyes, hand motions in eight, and light perception in three. Preoperative therapy included systemic chemotherapy (8 patients), mucous membrane grafting (9 eyes), lamellar keratoplasty (2 eyes), superficial keratectomy (1 eye), and corneal dye laser photocoagulation (6 eyes). The mean follow-up period was 4.6 years (3 months-13 years). Eight eyes (50%) had clear grafts, and three eyes (18.7%) had 20/200 or better visual acuity at last visit. The major causes of graft failure were epithelial defect formation/persistence, stromal ulceration, perforation, and graft rejection. CONCLUSIONS: These results indicate that PK may be performed for tectonic reasons, but prospects for restoration of sight in patients with advanced cicatrizing conjunctival diseases, even after extensive preoperative medical and surgical therapy, are limited.
|
Authors | I Tugal-Tutkun, Y A Akova, C S Foster |
Journal | Ophthalmology
(Ophthalmology)
Vol. 102
Issue 4
Pg. 576-85
(Apr 1995)
ISSN: 0161-6420 [Print] United States |
PMID | 7724175
(Publication Type: Case Reports, Journal Article)
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Conjunctival Diseases
(complications, pathology)
- Cornea
(pathology, surgery)
- Corneal Diseases
(surgery)
- Female
- Follow-Up Studies
- Humans
- Keratoplasty, Penetrating
- Male
- Middle Aged
- Pemphigoid, Benign Mucous Membrane
(complications, pathology)
- Prognosis
- Reoperation
- Visual Acuity
|