Diagnostic immunohistochemistry of cutaneous metastatic breast carcinoma: a statistical analysis of the utility of gross cystic disease fluid protein-15 and estrogen receptor protein.

Abstract

BACKGROUND:

For accurate classification of cutaneous metastatic carcinoma, reliable tumor-specific immunohistochemical markers would be valuable.

OBJECTIVE:

Our purpose was to analyze the sensitivity, specificity, and positive predictive value of gross cystic disease fluid protein-15 (GCDFP-15) and estrogen receptor protein (ERP) for diagnosing cutaneous metastatic breast carcinoma.

METHODS:

Tissue sections from 68 consecutive cases of cutaneous metastatic carcinoma were stained for GCDFP-15 and ERP. Hematoxylin-eosin-stained slides and immunostained slides were reviewed in a blinded fashion before retrospective chart review to ascertain the underlying primary tumor type.

RESULTS:

Of 42 cases of cutaneous metastatic breast carcinoma, 30 were positive for GCDFP-15. Of 41 cases of metastatic breast carcinoma, 30 were positive for ERP. Calculated sensitivity, specificity, and positive predictive value for GCDFP-15 for diagnosing cutaneous metastatic breast carcinoma were 71%, 91%, and 94%, respectively, and 73%, 100%, and 100% for ERP, respectively. Combined values of these indices for both stains were 83%, 91%, and 95%, respectively.

CONCLUSION:

GCDFP-15 and ERP are valuable markers for cutaneous metastatic breast carcinoma and should be used in combination.

• Authors: A H Ormsby, J L Snow, W P Su, J R Goellner
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 32 Issue 5 Pt 1 Pg. 711-6 (May 1995) ISSN: 0190-9622 [Print] United States
• PMID: 7722013 (Publication Type: Journal Article)

Chemical References

• APOD protein, human
• Apolipoproteins
• Apolipoproteins D
• Biomarkers, Tumor
• Carrier Proteins
• Glycoproteins
• Membrane Transport Proteins
• PIP protein, human
• Receptors, Estrogen
• estrophilin

Topics

• Apolipoproteins
• Apolipoproteins D
• Biomarkers, Tumor (analysis)
• Breast Neoplasms (pathology)
• Carrier Proteins (analysis)
• Female
• Glycoproteins
• Humans
• Immunohistochemistry
• Membrane Transport Proteins
• Predictive Value of Tests
• Receptors, Estrogen (analysis)
• Sensitivity and Specificity
• Skin Neoplasms (chemistry, diagnosis, secondary)