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Diagnostic immunohistochemistry of cutaneous metastatic breast carcinoma: a statistical analysis of the utility of gross cystic disease fluid protein-15 and estrogen receptor protein.

AbstractBACKGROUND:
For accurate classification of cutaneous metastatic carcinoma, reliable tumor-specific immunohistochemical markers would be valuable.
OBJECTIVE:
Our purpose was to analyze the sensitivity, specificity, and positive predictive value of gross cystic disease fluid protein-15 (GCDFP-15) and estrogen receptor protein (ERP) for diagnosing cutaneous metastatic breast carcinoma.
METHODS:
Tissue sections from 68 consecutive cases of cutaneous metastatic carcinoma were stained for GCDFP-15 and ERP. Hematoxylin-eosin-stained slides and immunostained slides were reviewed in a blinded fashion before retrospective chart review to ascertain the underlying primary tumor type.
RESULTS:
Of 42 cases of cutaneous metastatic breast carcinoma, 30 were positive for GCDFP-15. Of 41 cases of metastatic breast carcinoma, 30 were positive for ERP. Calculated sensitivity, specificity, and positive predictive value for GCDFP-15 for diagnosing cutaneous metastatic breast carcinoma were 71%, 91%, and 94%, respectively, and 73%, 100%, and 100% for ERP, respectively. Combined values of these indices for both stains were 83%, 91%, and 95%, respectively.
CONCLUSION:
GCDFP-15 and ERP are valuable markers for cutaneous metastatic breast carcinoma and should be used in combination.
AuthorsA H Ormsby, J L Snow, W P Su, J R Goellner
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 32 Issue 5 Pt 1 Pg. 711-6 (May 1995) ISSN: 0190-9622 [Print] UNITED STATES
PMID7722013 (Publication Type: Journal Article)
Chemical References
  • APOD protein, human
  • Apolipoproteins
  • Apolipoproteins D
  • Biomarkers, Tumor
  • Carrier Proteins
  • Glycoproteins
  • Membrane Transport Proteins
  • PIP protein, human
  • Receptors, Estrogen
  • estrophilin
Topics
  • Apolipoproteins
  • Apolipoproteins D
  • Biomarkers, Tumor (analysis)
  • Breast Neoplasms (pathology)
  • Carrier Proteins (analysis)
  • Female
  • Glycoproteins
  • Humans
  • Immunohistochemistry
  • Membrane Transport Proteins
  • Predictive Value of Tests
  • Receptors, Estrogen (analysis)
  • Sensitivity and Specificity
  • Skin Neoplasms (chemistry, diagnosis, secondary)

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