Abstract | OBJECTIVES AND METHODS: The aim of this multicentre, randomized open trial was to compare the efficacy and tolerance of 4-ASA vs 5-ASA enemas in the treatment of distal moderately active ulcerative colitis. Fifty patients were randomized to receive enemas in 100 mL suspension of 4-ASA (2 g, n = 26), or 5-ASA (1 g, n = 24). The subjects filled a daily questionnaire on enema retention duration, and tolerance. Clinical and endoscopic evaluations were performed at baseline and after 2 and 4 weeks. RESULTS: Significant clinical and endoscopic improvements occurred in both groups. Efficacy and enema retention time did not differ between groups. Tolerance was significantly better for 4-ASA: score 0.46 +/- 0.77 vs 1.00 +/- 0.73, P = 0.03. CONCLUSIONS: Efficacy of both treatments was equivalent, but 4-ASA enemas were better tolerated than 5-ASA in this open trial.
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Authors | P Marteau, M Halphen |
Journal | Gastroenterologie clinique et biologique
(Gastroenterol Clin Biol)
Vol. 19
Issue 1
Pg. 31-5
(Jan 1995)
ISSN: 0399-8320 [Print] France |
Vernacular Title | Etude comparative ouverte randomisée de l'efficacité et de la tolérance de lavements de 2 g d'acide 4-amino-salicylique (4-ASA) et de 1 g d'acide 5-amino-salicylique (5-ASA) dans les formes basses de rectocolite hémorragique. |
PMID | 7720988
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Aminosalicylic Acids
- Mesalamine
- Aminosalicylic Acid
|
Topics |
- Adult
- Aminosalicylic Acid
(administration & dosage, adverse effects, therapeutic use)
- Aminosalicylic Acids
(administration & dosage, adverse effects, therapeutic use)
- Colitis, Ulcerative
(complications, diagnostic imaging, drug therapy)
- Endoscopy, Gastrointestinal
- Enema
(methods)
- Female
- Gastrointestinal Hemorrhage
(drug therapy, etiology)
- Humans
- Male
- Mesalamine
- Middle Aged
- Radiography
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