[Comparative randomized open study of the efficacy and tolerance of enemas with 2 gr of 4-amino-salicylic acid (4-ASA) and 1 gr of 5-amino-salicylic acid (5-ASA) in distal forms of hemorrhagic rectocolitis].

Abstract

OBJECTIVES AND METHODS:

The aim of this multicentre, randomized open trial was to compare the efficacy and tolerance of 4-ASA vs 5-ASA enemas in the treatment of distal moderately active ulcerative colitis. Fifty patients were randomized to receive enemas in 100 mL suspension of 4-ASA (2 g, n = 26), or 5-ASA (1 g, n = 24). The subjects filled a daily questionnaire on enema retention duration, and tolerance. Clinical and endoscopic evaluations were performed at baseline and after 2 and 4 weeks.

RESULTS:

Significant clinical and endoscopic improvements occurred in both groups. Efficacy and enema retention time did not differ between groups. Tolerance was significantly better for 4-ASA: score 0.46 +/- 0.77 vs 1.00 +/- 0.73, P = 0.03.

CONCLUSIONS:

Efficacy of both treatments was equivalent, but 4-ASA enemas were better tolerated than 5-ASA in this open trial.

• Authors: P Marteau, M Halphen
• Journal: Gastroenterologie clinique et biologique (Gastroenterol Clin Biol) Vol. 19 Issue 1 Pg. 31-5 (Jan 1995) ISSN: 0399-8320 [Print] France
• Vernacular Title: Etude comparative ouverte randomisée de l'efficacité et de la tolérance de lavements de 2 g d'acide 4-amino-salicylique (4-ASA) et de 1 g d'acide 5-amino-salicylique (5-ASA) dans les formes basses de rectocolite hémorragique.
• PMID: 7720988 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Aminosalicylic Acids
• Mesalamine
• Aminosalicylic Acid

Topics

• Adult
• Aminosalicylic Acid (administration & dosage, adverse effects, therapeutic use)
• Aminosalicylic Acids (administration & dosage, adverse effects, therapeutic use)
• Colitis, Ulcerative (complications, diagnostic imaging, drug therapy)
• Endoscopy, Gastrointestinal
• Enema (methods)
• Female
• Gastrointestinal Hemorrhage (drug therapy, etiology)
• Humans
• Male
• Mesalamine
• Middle Aged
• Radiography