Abstract |
Previous studies indicated calcium channel blockers to be of some help for normal-tension glaucoma patients. The present study evaluates the effect of magnesium, a 'physiological calcium blocker', in 10 glaucoma patients (6 with primary open-angle glaucoma, 4 with normal-tension glaucoma). All patients had a digital cold-induced vasospasm. Magnesium (121.5 mg) was administered twice a day for a month. After 4 weeks of treatment, the visual fields tended to improve. All three video-nailfold-capillaroscopic parameters [blood cell velocity (in mm/s) before and after cooling, cold-induced blood flow cessation (in seconds) as well as the number of capillaries per microscopic field which showed such a blood flow cessation] as well as digital temperature improved significantly. Systemic blood pressure and pulse rate remained stable. In conclusion, magnesium improves the peripheral circulation and seems to have a beneficial effect on the visual field in glaucoma patients with vasospasm.
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Authors | A Z Gaspar, P Gasser, J Flammer |
Journal | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
(Ophthalmologica)
Vol. 209
Issue 1
Pg. 11-3
( 1995)
ISSN: 0030-3755 [Print] Switzerland |
PMID | 7715920
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Blood Flow Velocity
(drug effects, physiology)
- Blood Pressure
(drug effects, physiology)
- Female
- Glaucoma, Open-Angle
(drug therapy, physiopathology)
- Heart Rate
(drug effects, physiology)
- Humans
- Intraocular Pressure
- Magnesium
(administration & dosage, pharmacology)
- Male
- Middle Aged
- Vasoconstriction
- Visual Fields
(drug effects)
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