Comparison of a mixture of papaverine, phentolamine and prostaglandin E1 with other intracavernous injections.

Abstract

OBJECTIVE:

evaluation of a self-injection program with a mixture of papaverine, phentolamine and prostaglandin E1 (PGE1).

METHOD:

a self-injection program for erectile dysfunction was started by 48 patients, using a 1-ml mixture of 4.5 mg papaverine, 0.2 mg phentolamine and 1.5 micrograms PGE1. Patients completed a questionnaire at 6 weeks and at 3 months and were followed at the Outpatients Department for an average of 1 year.

RESULT:

of these patients 25 had previous experience with 20 micrograms PGE1 for intracavernous use and 22 patients had previously used 30 mg papaverine with 1 mg phentolamine. None of these 3 self-injection drugs is obviously superior in its ability to induce erections. Priapism occurred twice on a total of 1,290 injections. After 1-year follow-up, 4 patients had developed problems with fibrosis of the corpora, 2 of whom had encountered this problem also in a previous self-injection program.

CONCLUSION:

this triple mixture has the disadvantage of causing fibrosis and priapism in susceptible patients.

• Authors: W Meinhardt, A A Lycklama à Nijeholt, R F Kropman, P Vermeij, J Zwartendijk
• Journal: European urology (Eur Urol) Vol. 26 Issue 4 Pg. 319-21 ( 1994) ISSN: 0302-2838 [Print] Switzerland
• PMID: 7713130 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Drug Combinations
• Papaverine
• Alprostadil
• Phentolamine

Topics

• Alprostadil (administration & dosage, adverse effects)
• Drug Combinations
• Erectile Dysfunction (drug therapy)
• Fibrosis (chemically induced)
• Follow-Up Studies
• Humans
• Injections
• Male
• Papaverine (administration & dosage, adverse effects)
• Penile Erection (drug effects)
• Penis (pathology)
• Phentolamine (administration & dosage, adverse effects)
• Priapism (chemically induced)
• Self Administration