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Lecithin-cholesterol acryltransferase activity in patients with coronary artery disease examined by coronary angiography.

Abstract
This study grew out of observations of certain lecithin:cholesterol acyltransferase (LCAT) abnormalities in patients with atherosclerosis. We studied the interrelationships among LCAT, and total cholesterol, free and esterified cholesterol, cholesterol in individual lipoprotein fractions, triglycerides, phospholipids, free fatty acids, L-lactates in 90 angiographically examined patients with coronary artery disease and 30 control subjects without clinical manifestations of coronary artery disease. Results of the study showed LCAT activity to be significantly decreased (P < 0.05) in patients with single-, double-, or triple-vessel disease than in disease-free subjects. LCAT was also found to follow the stage of coronary artery disease in angiographically examined patients. Decreased LCAT activity was accompanied by lower high-density lipoprotein cholesterol, elevated ratio of unesterified to esterified cholesterol, and increased levels of L-lactates, free fatty acids, and low-density lipoprotein cholesterol. Total cholesterol and triglycerides were within or slightly above the normal limits. The results show LCAT to be a significantly better indicator of the risk of coronary artery disease than either total cholesterol or triglycerides.
AuthorsN Solajić-Bozicević, A Stavljenić-Rukavina, M Sesto
JournalThe Clinical investigator (Clin Investig) Vol. 72 Issue 12 Pg. 951-6 (Dec 1994) ISSN: 0941-0198 [Print] Germany
PMID7711425 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Phosphatidylcholine-Sterol O-Acyltransferase
Topics
  • Adult
  • Aged
  • Biomarkers (blood)
  • Coronary Angiography
  • Coronary Disease (blood, diagnostic imaging)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phosphatidylcholine-Sterol O-Acyltransferase (blood)
  • Predictive Value of Tests
  • Sex Distribution

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