Abstract |
Recent observations have shown that the pineal hormone melatonin (MLT) may modulate oestrogen receptor (ER) expression and inhibit breast cancer cell growth. On this basis, we have evaluated the biological and clinical effects of a concomitant MLT therapy in women with metastatic breast cancer who had progressed in response to tamoxifen (TMX) alone. The study included 14 patients with metastasis who did not respond (n = 3) to therapy with TMX alone or progressed after initial stable disease (SD) (n = 11). MLT was given orally at 20 mg day-1 in the evening, every day starting 7 days before TMX, which was given orally at 20 mg day-1 at noon. A partial response was achieved in 4/14 (28.5%) patients (median duration 8 months). The treatment was well tolerated in all cases, and no MLT-induced enhancement of TMX toxicity was seen; on the contrary, most patients experienced a relief of anxiety. Mean serum levels of insulin-like growth factor 1 (IGF-1), which is a growth factor for breast cancer, significantly decreased on therapy, and this decline was significantly higher in responders than in patients with SD or progression. This pilot phase II study would suggest that the concomitant administration of the pineal hormone MLT may induce objective tumour regressions in metastatic breast cancer patients refractory to TMX alone.
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Authors | P Lissoni, S Barni, S Meregalli, V Fossati, M Cazzaniga, D Esposti, G Tancini |
Journal | British journal of cancer
(Br J Cancer)
Vol. 71
Issue 4
Pg. 854-6
(Apr 1995)
ISSN: 0007-0920 [Print] England |
PMID | 7710954
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Tamoxifen
- Insulin-Like Growth Factor I
- Melatonin
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Topics |
- Adult
- Aged
- Breast Neoplasms
(blood, therapy)
- Female
- Humans
- Insulin-Like Growth Factor I
(analysis)
- Melatonin
(therapeutic use, toxicity)
- Middle Aged
- Neoplasm Metastasis
- Tamoxifen
(therapeutic use, toxicity)
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