Abstract | PURPOSE: To evaluate immunohistochemical staining of the endothelia of corneas from patients with clinical diagnoses of iridocorneal endothelial ( ICE) syndrome. METHODS: RESULTS: There was almost universal staining of the endothelial layer with A1 and A3 keratin monoclonal antibodies and vimentin. Transmission electron microscopy of the corneas also confirmed features consistent with keratin. CONCLUSIONS: The "endothelial" cell layer in the iridocorneal endothelial syndrome has electron microscopic and immunohistochemical characteristics of epithelial-like cells, but it also cross-reacts with vimentin, suggesting that these cells retain or derive some endothelial staining characteristics as well. This "epithelialization" of the endothelial layer may explain the progressive cellular proliferation across angle and iris similar to that seen in iatrogenic epithelial downgrowth and posterior polymorphous endothelial dystrophy.
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Authors | L W Hirst, J Bancroft, K Yamauchi, W R Green |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 36
Issue 5
Pg. 820-7
(Apr 1995)
ISSN: 0146-0404 [Print] United States |
PMID | 7706030
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Intermediate Filament Proteins
- Nerve Tissue Proteins
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Topics |
- Adult
- Aged
- Corneal Diseases
(metabolism, pathology)
- Endothelium, Corneal
(metabolism, ultrastructure)
- Female
- Fluorescent Antibody Technique
- Glaucoma
(metabolism, pathology)
- Humans
- Intermediate Filament Proteins
(analysis)
- Intermediate Filaments
(chemistry)
- Iris Diseases
(metabolism, pathology)
- Male
- Middle Aged
- Nerve Tissue Proteins
(analysis)
- Syndrome
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