Renal function in Laron syndrome patients treated by insulin-like growth factor-I.

Abstract

Eight children with Laron syndrome (5 males, 3 females) aged 3-14.5 years received daily subcutaneous injections of 150 micrograms/kg recombinant insulin-like growth factor-I (IGF-I) for 5 months. The children were examined weekly for the 1st month and then once monthly. At each visit, overnight fasting blood was drawn for serum IGF-I and blood chemistry measurements and a 24-h urine collection was performed for the determination of calcium, phosphorus, creatinine and nitrogen. The main effects related to kidney function were: an initial weight gain with a mild transitory reduction in the urinary volume, an increase in serum electrolyte concentrations and a decrease in urinary electrolyte excretion. The lower than normal mean (+/- SEM) basal creatinine clearance (76.7 +/- 15.8 ml/min per 1.73 m2) increased towards the normal range during treatment to 124.9 +/- 13 ml/min per 1.73 m2, with a mean increment of 73.4 +/- 28% (P < 0.02) from basal values after 2 months of treatment, without changes in the serum creatinine. Initially an increase in blood urea nitrogen was observed together with a reduction in urinary nitrogen excretion. During the IGF-I therapy the urinary calcium excretion increased from 0.7 +/- 0.2 nmol/day to 1.5 +/- 0.3 nmol/day and the tubular reabsorption of phosphate increased from 1.24 +/- 0.06 to more than 1.38 +/- 0.04 nmol/l (P < 0.002), resulting in a significant increase in serum phosphate levels from 1.51 +/- 0.06 to more than 1.63 +/- 0.04 nmol/l (P < 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: B Klinger, Z Laron
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 8 Issue 6 Pg. 684-8 (Dec 1994) ISSN: 0931-041X [Print] Germany
• PMID: 7696105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Electrolytes
• Phosphorus
• Insulin-Like Growth Factor I
• Creatinine
• Receptor, IGF Type 1
• Alkaline Phosphatase
• Nitrogen

Topics

• Adolescent
• Alkaline Phosphatase (blood)
• Blood Urea Nitrogen
• Child
• Child, Preschool
• Creatinine (blood, urine)
• Electrolytes (blood, urine)
• Female
• Growth Disorders (drug therapy, genetics, physiopathology)
• Humans
• Insulin-Like Growth Factor I (therapeutic use)
• Kidney (drug effects, physiopathology)
• Male
• Nitrogen (urine)
• Phosphorus (blood)
• Photometry
• Receptor, IGF Type 1 (deficiency)
• Syndrome