Human peripheral myelin protein-22 carries the L2/HNK-1 carbohydrate adhesion epitope.

Abstract

Molecular genetic studies have established that mutations in the gene encoding the 22-kDa peripheral myelin protein (PMP-22) are responsible for hereditary peripheral neuropathies in the trembler mouse and in a subset of humans with Charcot-Marie-Tooth disease, type 1a. The function of the PMP-22 protein remains unknown. Several studies on myelin proteins in the PNS have indicated that the L2/HNK-1 epitope, which is believed to be both a ligand for cellular adhesion and a target for autoimmune monoclonal IgM neuritis, may be found on heretofore unidentified proteins with a molecular mass of 19-28 kDa. In this report, we provide immunological evidence that at least one of these proteins is PMP-22.

• Authors: G J Snipes, U Suter, E M Shooter
• Journal: Journal of neurochemistry (J Neurochem) Vol. 61 Issue 5 Pg. 1961-4 (Nov 1993) ISSN: 0022-3042 [Print] England
• PMID: 7693873 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies
• Antigens, CD
• Antigens, Differentiation, T-Lymphocyte
• CD57 Antigens
• Epitopes
• Myelin Proteins
• PMP22 protein, human
• Peptides
• Pmp22 protein, mouse

Topics

• Amino Acid Sequence
• Antibodies
• Antigens, CD (chemistry, immunology)
• Antigens, Differentiation, T-Lymphocyte (chemistry, immunology)
• Blotting, Western
• CD57 Antigens
• Cauda Equina (chemistry)
• Electrophoresis, Polyacrylamide Gel
• Epitopes (analysis)
• Humans
• Molecular Sequence Data
• Molecular Weight
• Myelin Proteins (chemistry, immunology, isolation & purification)
• Myelin Sheath (chemistry)
• Peptides (chemical synthesis, immunology)
• Peripheral Nerves (chemistry)