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Granulocyte-colony stimulating factor therapy in drug-induced agranulocytosis.

Abstract
Drug-induced agranulocytosis in the outpatient setting is a rare but potentially fatal adverse effect of many classes of medications. Five patients with this disorder presented to Yale-New Haven (Conn) Hospital during 1990 through 1992. Three patients treated with granulocyte-colony stimulating factor and two patients treated with routine care were studied for relevant clinical outcomes. Treatment with granulocyte-colony stimulating factor was associated with a shorter duration of neutropenia and a decreased length of hospital stay, consistent with recent case reports. Despite the high cost of the drug, treatment with granulocyte-colony stimulating factor was found to be cost-effective for patients with uncomplicated drug-induced agranulocytosis.
AuthorsS Mani, M Barry, J Concato
JournalArchives of internal medicine (Arch Intern Med) Vol. 153 Issue 21 Pg. 2500-1 (Nov 08 1993) ISSN: 0003-9926 [Print] United States
PMID7692832 (Publication Type: Journal Article)
Chemical References
  • Granulocyte Colony-Stimulating Factor
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Agranulocytosis (chemically induced, drug therapy)
  • Female
  • Granulocyte Colony-Stimulating Factor (economics, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome

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