Biological response modifier-mediated resistance to herpesvirus infections requires induction of alpha/beta interferon.

Abstract	The role of interferon alpha/beta (IFN) induction by the immunomodulators pICLC and CL246,738 was investigated in CD-1 mice infected with murine cytomegalovirus (MCMV) or herpes simplex virus type 2 (HSV-2). Mice were treated with either normal sheep serum or anti-alpha/beta IFN antiserum, inoculated with the immunomodulators, and infected with virus. Because anti-IFN treatment also decreased natural resistance to HSV-2 and MCMV, two viral challenge doses were used to ensure that the mice with control serum or anti-IFN antiserum received biologically equivalent infections. Antiviral protection of pICLC and CL246,738 against HSV-2 infection was completely abrogated by treatment with anti-alpha/beta interferon antiserum. Mice treated with pICLC also lost antiviral protection against MCMV when interferon alpha/beta was depleted. These results indicate that induction of interferon alpha/beta appears to be a major mechanism for both natural resistance and pICLC-induced antiviral protection against MCMV and HSV-2 herpesvirus infections.
Authors	S C Kunder, K M Kelly, P S Morahan
Journal	Antiviral research (Antiviral Res) Vol. 21 Issue 2 Pg. 129-39 (Jun 1993) ISSN: 0166-3542 [Print] Netherlands
PMID	7687839 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Acridines Immunologic Factors Interferon Inducers Interferon-alpha Polylysine Interferon-beta poly ICLC 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride Interferons Carboxymethylcellulose Sodium Poly I-C
Topics	Acridines (pharmacology) Animals Carboxymethylcellulose Sodium (pharmacology) Cytomegalovirus Infections (immunology) Female Herpes Simplex (immunology) Herpesviridae Infections (immunology) Immunity, Innate (drug effects) Immunologic Factors (pharmacology) Interferon Inducers (pharmacology) Interferon-alpha (biosynthesis) Interferon-beta (biosynthesis) Interferons (biosynthesis) Mice Mice, Inbred Strains Poly I-C (pharmacology) Polylysine (pharmacology) Specific Pathogen-Free Organisms Survival Analysis

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