Abstract |
Synthetic peptides corresponding to germline TCR V beta 8.2 sequences overexpressed by Lewis rat encephalitogenic T cells are effective in the prevention and treatment of autoimmune encephalomyelitis (EAE). In evaluating optimal conditions for identifying disease-relevant target V beta genes, we found that the biased expression of V beta 8.2 was most pronounced in the CNS among activated, IL-2 responsive T cells, but was weakly reflected in the cerebrospinal fluid. Evaluation of basic protein reactive T cells from patients with multiple sclerosis revealed biased expression of V beta 5.2 and to a lesser degree, V beta 6.1. Treatment of 11 MS patients with synthetic TCR V beta 5.2 and V beta 6.1 CDR2 peptides boosted the frequency of anti-TCR reactive T cells in a majority of patients, without compromising recall immunity or causing side effects. TCR peptides may be useful in the treatment of human autoimmune diseases, providing that disease-relevant V genes can be identified.
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Authors | A A Vandenbark, D N Bourdette, R Whitham, Y K Chou, G A Hashim, H Offner |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
1993 Mar-Apr
Vol. 11 Suppl 8
Pg. S51-3
ISSN: 0392-856X [Print] Italy |
PMID | 7686833
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Myelin Basic Protein
- Peptides
- Receptors, Antigen, T-Cell, alpha-beta
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Topics |
- Animals
- Arthritis, Rheumatoid
(etiology)
- Encephalomyelitis, Autoimmune, Experimental
(immunology, therapy)
- Humans
- Immunotherapy
- Mice
- Multiple Sclerosis
(immunology, therapy)
- Myelin Basic Protein
(immunology)
- Peptides
(chemical synthesis, immunology, therapeutic use)
- Rats
- Rats, Inbred Lew
- Receptors, Antigen, T-Cell, alpha-beta
(genetics, immunology)
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