T-cell receptor peptide therapy in EAE and MS.

Abstract

Synthetic peptides corresponding to germline TCR V beta 8.2 sequences overexpressed by Lewis rat encephalitogenic T cells are effective in the prevention and treatment of autoimmune encephalomyelitis (EAE). In evaluating optimal conditions for identifying disease-relevant target V beta genes, we found that the biased expression of V beta 8.2 was most pronounced in the CNS among activated, IL-2 responsive T cells, but was weakly reflected in the cerebrospinal fluid. Evaluation of basic protein reactive T cells from patients with multiple sclerosis revealed biased expression of V beta 5.2 and to a lesser degree, V beta 6.1. Treatment of 11 MS patients with synthetic TCR V beta 5.2 and V beta 6.1 CDR2 peptides boosted the frequency of anti-TCR reactive T cells in a majority of patients, without compromising recall immunity or causing side effects. TCR peptides may be useful in the treatment of human autoimmune diseases, providing that disease-relevant V genes can be identified.

• Authors: A A Vandenbark, D N Bourdette, R Whitham, Y K Chou, G A Hashim, H Offner
• Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol) 1993 Mar-Apr Vol. 11 Suppl 8 Pg. S51-3 ISSN: 0392-856X [Print] Italy
• PMID: 7686833 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Myelin Basic Protein
• Peptides
• Receptors, Antigen, T-Cell, alpha-beta

Topics

• Animals
• Arthritis, Rheumatoid (etiology)
• Encephalomyelitis, Autoimmune, Experimental (immunology, therapy)
• Humans
• Immunotherapy
• Mice
• Multiple Sclerosis (immunology, therapy)
• Myelin Basic Protein (immunology)
• Peptides (chemical synthesis, immunology, therapeutic use)
• Rats
• Rats, Inbred Lew
• Receptors, Antigen, T-Cell, alpha-beta (genetics, immunology)