Abstract | AIM: METHOD: One hundred and five patients with otitis externa agreed to enter the trial; 13 of these had bilateral otitis externa. Six symptoms and signs of otitis externa were rated on a scale of 1 (none) to 5 (severe) and then the scores were averaged to give an index of severity. Swabs from all infected ears were cultured and then the patients were treated with Kenacomb ointment. Patients were randomly assigned to take a five-day course of either oral cotrimoxazole or an oral placebo and were reassessed on Days 2-4 and Days 5-6 after presentation. RESULTS: The mean duration (+/- standard deviation) of ear pain from the first visit for the cotrimoxazole and placebo groups was 3.1 (+/- 1.5) days and 3.1 (+/- 1.7) days respectively. The mean severity indices (+/- standard deviation) for these groups on presentation were 2.33 (+/- 0.59) and 2.37 (+/- 0.57). The respective reductions in these scores by the second visit were 0.72 and 0.69 and by the third visit 1.10 and 1.05. The principle pathogen isolated was Pseudomonas aeruginosa. CONCLUSION:
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Authors | M J Yelland |
Journal | The Medical journal of Australia
(Med J Aust)
Vol. 158
Issue 10
Pg. 697-9
(May 17 1993)
ISSN: 0025-729X [Print] Australia |
PMID | 7683742
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Drug Combinations
- Gramicidin, Neomycin Sulfate, Nystatin, Triamcinolone Acetonide Drug Combination
- Placebos
- Tablets
- Nystatin
- Gramicidin
- Trimethoprim, Sulfamethoxazole Drug Combination
- Triamcinolone Acetonide
- Neomycin
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Topics |
- Administration, Oral
- Adult
- Child
- Double-Blind Method
- Drug Combinations
- Earache
(drug therapy)
- Female
- Gramicidin
(administration & dosage, therapeutic use)
- Humans
- Male
- Neomycin
(administration & dosage, therapeutic use)
- Nystatin
(administration & dosage, therapeutic use)
- Otitis Externa
(drug therapy, microbiology)
- Placebos
- Pseudomonas Infections
(drug therapy)
- Pseudomonas aeruginosa
- Staphylococcal Infections
(drug therapy)
- Tablets
- Triamcinolone Acetonide
(administration & dosage, therapeutic use)
- Trimethoprim, Sulfamethoxazole Drug Combination
(administration & dosage, therapeutic use)
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