Abstract |
The effects of a novel opioid kappa-receptor agonist U-50488H on Na(+)-K(+)- adenosine triphosphatase ( ATPase) activity and regional cerebral blood flow (rCBF) were studied in the acute ischemic brain of rats after middle cerebral artery (MCA) occlusion. Administration of U-50488H 15 minutes prior to MCA occlusion attenuated ischemic reduction in Na(+)-K(+)- ATPase activity 15 minutes after MCA occlusion. The effect was statistically significant at a dosage of 30 mg/kg, but not at lower doses (0.3 and 3 mg/kg). There was no effect on rCBF before MCA occlusion, and the decreased flow after occlusion was enhanced with a significant fall in systemic blood pressure at a dosage of 30 mg/kg. These results indicate that U-50488H has therapeutic potential in cerebral ischemia by mechanisms other than improvement in CBF.
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Authors | T Furui |
Journal | Neurologia medico-chirurgica
(Neurol Med Chir (Tokyo))
Vol. 33
Issue 3
Pg. 133-8
(Mar 1993)
ISSN: 0470-8105 [Print] Japan |
PMID | 7683118
(Publication Type: Journal Article)
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Chemical References |
- Antihypertensive Agents
- Pyrrolidines
- Receptors, Opioid, kappa
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
- Sodium-Potassium-Exchanging ATPase
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Topics |
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
- Animals
- Antihypertensive Agents
(pharmacology)
- Blood Pressure
(drug effects, physiology)
- Brain
(blood supply)
- Brain Damage, Chronic
(physiopathology)
- Brain Ischemia
(physiopathology)
- Male
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, Opioid, kappa
(drug effects, physiology)
- Regional Blood Flow
(drug effects, physiology)
- Sodium-Potassium-Exchanging ATPase
(drug effects, physiology)
- Synaptic Membranes
(drug effects, physiology)
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