Abstract |
In order to evaluate a possible antiarrhythmic action of L-carnitine (C) in ischemic heart disease, 30 patients (20 males, 10 females, average age 64 years +/- 11) with ischemic heart disease who at examination with 24-hour dynamic ECG showed extrasystolic ventricular multifocal arrhythmia with a mean hourly rate of > 300 were randomized into three groups, the first of which was given a daily oral dose of 6 g C in three divided doses; groups 2 and 3 were given propafenone (P), 900 mg daily in three divided doses. After one week, all patients were again submitted to 24-hour dynamic ECG after which treatment was continued for another week as follows: group 1 continued on C (6 g daily), group 2 continued on P (900 mg daily), group 3 continued on P (900 mg daily) plus C (6 g daily). At the end of the second week, a further 24-hour ECG was performed the results of which showed that L-carnitine can significantly reduce the antiarrhythmic activity of the ischemic myocardium. In addition, at the end of the second week, a further significant reduction of the number of premature beats compared to the first week was found in patients for whom L-carnitine had been added to propafenone treatment.
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Authors | V Palazzuoli, S Mondillo, S Faglia, N D'Aprile, A Camporeale, C Gennari |
Journal | La Clinica terapeutica
(Clin Ter)
Vol. 142
Issue 2
Pg. 155-9
(Feb 1993)
ISSN: 0009-9074 [Print] Italy |
Vernacular Title | Valutazione dell'attività antiaritmica della L-carnitina e del propafenone nella cardiopatia ischemica. |
PMID | 7682488
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Arrhythmia Agents
- Propafenone
- Carnitine
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Topics |
- Aged
- Anti-Arrhythmia Agents
(therapeutic use)
- Cardiac Complexes, Premature
(drug therapy, etiology)
- Carnitine
(therapeutic use)
- Drug Therapy, Combination
- Electrocardiography
(drug effects)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Ischemia
(complications, drug therapy)
- Propafenone
(therapeutic use)
- Remission Induction
- Time Factors
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