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[The evaluation of the antiarrhythmic activity of L-carnitine and propafenone in ischemic cardiopathy].

Abstract
In order to evaluate a possible antiarrhythmic action of L-carnitine (C) in ischemic heart disease, 30 patients (20 males, 10 females, average age 64 years +/- 11) with ischemic heart disease who at examination with 24-hour dynamic ECG showed extrasystolic ventricular multifocal arrhythmia with a mean hourly rate of > 300 were randomized into three groups, the first of which was given a daily oral dose of 6 g C in three divided doses; groups 2 and 3 were given propafenone (P), 900 mg daily in three divided doses. After one week, all patients were again submitted to 24-hour dynamic ECG after which treatment was continued for another week as follows: group 1 continued on C (6 g daily), group 2 continued on P (900 mg daily), group 3 continued on P (900 mg daily) plus C (6 g daily). At the end of the second week, a further 24-hour ECG was performed the results of which showed that L-carnitine can significantly reduce the antiarrhythmic activity of the ischemic myocardium. In addition, at the end of the second week, a further significant reduction of the number of premature beats compared to the first week was found in patients for whom L-carnitine had been added to propafenone treatment.
AuthorsV Palazzuoli, S Mondillo, S Faglia, N D'Aprile, A Camporeale, C Gennari
JournalLa Clinica terapeutica (Clin Ter) Vol. 142 Issue 2 Pg. 155-9 (Feb 1993) ISSN: 0009-9074 [Print] Italy
Vernacular TitleValutazione dell'attività antiaritmica della L-carnitina e del propafenone nella cardiopatia ischemica.
PMID7682488 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Arrhythmia Agents
  • Propafenone
  • Carnitine
Topics
  • Aged
  • Anti-Arrhythmia Agents (therapeutic use)
  • Cardiac Complexes, Premature (drug therapy, etiology)
  • Carnitine (therapeutic use)
  • Drug Therapy, Combination
  • Electrocardiography (drug effects)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Ischemia (complications, drug therapy)
  • Propafenone (therapeutic use)
  • Remission Induction
  • Time Factors

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