Effects of mitomycin C on delayed adjustment in experimental strabismus surgery.

Abstract

In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.

• Authors: S O Oh, B L Chang, J Lee
• Journal: Korean journal of ophthalmology : KJO (Korean J Ophthalmol) Vol. 9 Issue 1 Pg. 51-8 (Jun 1995) ISSN: 1011-8942 [Print] Korea (South)
• PMID: 7674553 (Publication Type: Journal Article)

Chemical References

• Ophthalmic Solutions
• Mitomycin

Topics

• Administration, Topical
• Animals
• Chemotherapy, Adjuvant
• Conjunctiva (drug effects)
• Mitomycin (administration & dosage, pharmacology)
• Oculomotor Muscles (drug effects, pathology, surgery)
• Ophthalmic Solutions
• Postoperative Complications (prevention & control)
• Rabbits
• Sclera (drug effects)
• Strabismus (drug therapy, pathology, surgery)
• Suture Techniques
• Tissue Adhesions (prevention & control)