Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: Myocardial alpha-adrenergic receptor blockade causes significant inotropic and lusitropic effects in the failing but not the nonfailing human LV. These effects appear to be mediated by increased release of norepinephrine from cardiac nerves secondary to blockade of presynaptic alpha 2-adrenergic receptors. Differences in the responses of the failing and nonfailing human LV appear to reflect the higher level of sympathetic activation that is seen in the group with congestive heart failure. This suggests that the presynaptic alpha 2-adrenergic receptor exerts a tonic inhibitory effect on the release of norepinephrine from cardiac nerves in patients with congestive heart failure.
|
Authors | J D Parker, G E Newton, J S Landzberg, J S Floras, W S Colucci |
Journal | Circulation
(Circulation)
Vol. 92
Issue 7
Pg. 1793-800
(Oct 01 1995)
ISSN: 0009-7322 [Print] United States |
PMID | 7671363
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Adrenergic alpha-Antagonists
- Receptors, Adrenergic, alpha
- Norepinephrine
- Phentolamine
|
Topics |
- Adrenergic alpha-Antagonists
(pharmacology)
- Cardiac Catheterization
- Case-Control Studies
- Female
- Heart Failure
(physiopathology)
- Humans
- Male
- Middle Aged
- Myocardial Contraction
(drug effects, physiology)
- Norepinephrine
(metabolism)
- Phentolamine
(pharmacology)
- Presynaptic Terminals
(drug effects, physiology)
- Receptors, Adrenergic, alpha
(drug effects, physiology)
- Ventricular Function, Left
(drug effects, physiology)
|