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Acute myeloblastic leukaemia without Philadelphia chromosome developing after interferon therapy for chronic myelocytic leukaemia with Philadelphia chromosome.

Abstract
We report a patient who developed Philadelphia chromosome negative acute myeloblastic leukaemia with trisomy 8 and trisomy 11 after receiving treatment with alkylating agents and interferon for chronic myelocytic leukaemia positive for Philadelphia chromosome. Leukaemic cells were positive for myeloperoxidase and expressed CD13, CD33 and DR; some expressed CD2, CD4 and CD34. The fluorescence in situ hybridization method revealed that bcr-abl fusion genes were absent from > 90% of the bone marrow cells. The major bcr rearrangement was not detected by Southern blot analysis. We conclude that the leukaemic cells negative for Philadelphia chromosome may have developed as a result of treatment with alkylating agents and interferon in the present case.
AuthorsE Ohtsuka, H Kikuchi, Y Abe, K Moriyama, E Ohno, K Hirota, K Tezono, M Nasu
JournalBritish journal of haematology (Br J Haematol) Vol. 90 Issue 4 Pg. 951-3 (Aug 1995) ISSN: 0007-1048 [Print] England
PMID7669678 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Interferon-alpha
  • Busulfan
Topics
  • Aged
  • Busulfan (therapeutic use)
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 8
  • Humans
  • Interferon-alpha (adverse effects, therapeutic use)
  • Karyotyping
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive (genetics, therapy)
  • Leukemia, Myeloid, Acute (etiology)
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (therapy)
  • Male
  • Trisomy

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