Abstract | OBJECTIVE: To examine the short-term cardiorespiratory effects of intravenous morphine infusion in ventilated preterm infants. METHODOLOGY: RESULTS:
Morphine-treated infants spent a significantly greater percentage of total ventilated time breathing in synchrony with their ventilators (median [IQ] = 72[58-87] vs 31[17-51]%; P = 0.0008). Heart rate and respiratory rate, but not blood pressure, were reduced in morphine-treated infants. Duration of oxygen therapy was reduced (median [IQ] = 4.5[3-7] vs 8[4.75-12.5] days; P = 0.046). CONCLUSIONS:
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Authors | M P Dyke, R Kohan, S Evans |
Journal | Journal of paediatrics and child health
(J Paediatr Child Health)
Vol. 31
Issue 3
Pg. 176-9
(Jun 1995)
ISSN: 1034-4810 [Print] Australia |
PMID | 7669374
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Double-Blind Method
- Hemodynamics
(drug effects)
- Humans
- Hyaline Membrane Disease
(physiopathology, therapy)
- Infant, Newborn
- Infant, Premature, Diseases
(physiopathology, therapy)
- Infusions, Intravenous
- Injections, Intravenous
- Length of Stay
- Morphine
(administration & dosage, therapeutic use)
- Oxygen Inhalation Therapy
- Respiration
(drug effects)
- Respiration, Artificial
(adverse effects)
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