Inhalation of nitric oxide as a treatment of pulmonary hypertension in congenital diaphragmatic hernia.

Abstract

Congenital diaphragmatic hernia (CDH) still has a mortality risk of around 40%. The concomitant pulmonary hypoplasia and the persistent pulmonary hypertension are of major prognostic importance. The use of a selective pulmonary vasodilator may revert this vicious circle that is fatal to many children. Inhalation of nitric oxide (NO) has been suggested as a rational treatment of this condition. The authors report three cases of high-risk infants with CDH where NO was used successfully. It is concluded that hypoxemia in CDH can be treated successfully with NO inhalation when conventional treatment fails, and it may in some cases prove to be an alternative to ECMO.

• Authors: S W Henneberg, S Jepsen, P K Andersen, S A Pedersen
• Journal: Journal of pediatric surgery (J Pediatr Surg) Vol. 30 Issue 6 Pg. 853-5 (Jun 1995) ISSN: 0022-3468 [Print] United States
• PMID: 7666321 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nitric Oxide

Topics

• Administration, Inhalation
• Female
• Hernia, Diaphragmatic (complications)
• Hernias, Diaphragmatic, Congenital
• Humans
• Hypertension, Pulmonary (drug therapy, etiology)
• Hypoxia (drug therapy, etiology)
• Infant, Newborn
• Male
• Nitric Oxide (administration & dosage, therapeutic use)