A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema.

Abstract

Topical photochemotherapy with psoralen and its derivatives 4,5',8-trimethylpsoralen (TMP) and 8-methoxypsoralen (8-MOP), with UVA irradiation, was evaluated with regard to minimum phototoxic dose, concentration, timing of UVA irradiation and systemic and local side-effects, in healthy volunteers. Psoralen (0.005%) in aqueous gel was found to be superior to TMP and 8-MOP in aqueous gel. No hyperpigmentation was seen after topical PUVA treatment with psoralen in aqueous gel. Patients with plaque-type psoriasis (n = 7), palmoplantar psoriasis (n = 7) and hyperkeratotic eczema (n = 2) were treated. Topical PUVA therapy was effective in most psoriasis patients, without the occurrence of local or systemic side-effects. Moreover, hyperkeratotic eczema patients who did not respond to conventional therapy showed partial remission. These results indicate that topical PUVA therapy with psoralen in aqueous gel is a useful therapeutic modality for treatment of psoriasis patients, and patients with recalcitrant dermatoses such as palmoplantar psoriasis and hyperkeratotic eczema.

• Authors: M A De Rie, J P Van Eendenburg, A C Versnick, L M Stolk, J D Bos, W Westerhof
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 132 Issue 6 Pg. 964-9 (Jun 1995) ISSN: 0007-0963 [Print] England
• PMID: 7662576 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Gels
• Ficusin
• Methoxsalen
• Trioxsalen

Topics

• Eczema (drug therapy)
• Ficusin (administration & dosage)
• Gels
• Humans
• Male
• Methoxsalen (administration & dosage)
• PUVA Therapy
• Psoriasis (drug therapy)
• Trioxsalen (administration & dosage)