Abstract | OBJECTIVE: METHODS:
Myocardial infarction was produced in SHR and WKY by coronary artery ligation. Haemodynamic measurements were obtained three weeks later in rats that had been treated from the next day after the operation for three weeks with TCV-116 (1 mg.kg-1.d-1) or delapril (1 g.litre-1 in drinking water), and in untreated controls. RESULTS: After myocardial infarction, left ventricular weight, and left ventricular weight were greater in SHR than in normotensive rats. Right ventricular weight, left ventricular end diastolic pressure, and LVEDVI correlated positively with infarct size in both SHR and WKY and these slopes were steeper in SHR than in WKY (P < 0.05). TCV-116 and delapril each significantly attenuated the increases in left ventricular end diastolic pressure, left ventricular weight, right ventricular weight, and LVEDVI following myocardial infarction in both in WKY and SHR, and shifted pressure-volume curve significantly to the left. CONCLUSIONS:
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Authors | T Nishikimi, H Yamagishi, K Takeuchi, T Takeda |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 29
Issue 6
Pg. 856-61
(Jun 1995)
ISSN: 0008-6363 [Print] England |
PMID | 7656290
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Benzimidazoles
- Biphenyl Compounds
- Indans
- Tetrazoles
- candesartan cilexetil
- delapril
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Benzimidazoles
(pharmacology)
- Biphenyl Compounds
(pharmacology)
- Cardiomyopathy, Dilated
(etiology, prevention & control)
- Hemodynamics
(drug effects)
- Hypertension
(complications)
- Indans
(pharmacology)
- Male
- Myocardial Infarction
(complications)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Tetrazoles
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