Smoldering gamma delta T-cell granular lymphocytic leukemia associated with pure red cell aplasia.

Abstract

We present a case of granular lymphocytic leukemia (GLL) associated with pure red cell aplasia (PRCA). Twenty-seven percent of the peripheral blood mononuclear cells (PBMC) were positive for TCR delta 1, but not for delta TCS1 (V delta 2), and a rearrangement of the TCR chain (J delta 1) gene was detected. The PBMC and serum from the patient slightly suppressed CFU-E but not BFU-E colony formation in vitro. These findings suggest that monoclonal proliferation of TCR gamma delta-positive granular lymphocytes (GL) can be associated with PRCA even in a patient having a small proportion of leukemia GL, which we propose to designate as 'smoldering GLL'.

• Authors: S Mori, H Suzushima, K Nishikawa, H Miyake, Y Yonemura, N Tsuji, T Kawaguchi, N Asou, M Kawakita, K Takatsuki
• Journal: Acta haematologica (Acta Haematol) Vol. 94 Issue 1 Pg. 32-5 ( 1995) ISSN: 0001-5792 [Print] Switzerland
• PMID: 7653209 (Publication Type: Case Reports, Journal Article)

Chemical References

• Receptors, Antigen, T-Cell, gamma-delta

Topics

• Colony-Forming Units Assay
• Erythrocyte Count
• Erythroid Precursor Cells
• Fluorescent Antibody Technique
• Gene Rearrangement, T-Lymphocyte
• Humans
• Leukemia, Lymphoid (complications, immunology)
• Leukemia, T-Cell (complications)
• Leukocytes, Mononuclear (immunology)
• Male
• Middle Aged
• Receptors, Antigen, T-Cell, gamma-delta (analysis, genetics)
• Red-Cell Aplasia, Pure (complications)