Abstract |
Endogenous hyperthermia was induced in rabbits by i.v. pyrogenal administration. Hemoglobin- oxygen affinity and parameters of free radical lipid oxidation in plasma and red blood cells were measured. The content of diene conjugates, malonic dialdehyde and Schiff bases were determined at a pyrogenal dose of 4 minimal pyrogenic doses/kg, and iron-initiated chemiluminescence, catalase activity and alpha-tocopherol concentration were determined at 6 minimal pyrogenic doses/kg. A rightward shift of the real oxyhemoglobin dissociation curve and activation of lipid peroxidation were observed. Relationships between the parameters measured were analyzed. Decreased hemoglobin- oxygen affinity is considered to be a possible mechanism of activation of free radicals during fever.
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Authors | M V Borisiuk, V V Zinchuk |
Journal | Acta biochimica Polonica
(Acta Biochim Pol)
Vol. 42
Issue 1
Pg. 69-74
( 1995)
ISSN: 0001-527X [Print] Poland |
PMID | 7653164
(Publication Type: Journal Article)
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Chemical References |
- Ferrous Compounds
- Free Radicals
- Lipopolysaccharides
- Oxyhemoglobins
- Pyrogens
- Schiff Bases
- pyrogenal
- Vitamin E
- ferrous sulfate
- Malondialdehyde
- Catalase
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Topics |
- Animals
- Body Temperature
- Catalase
(metabolism)
- Erythrocytes
(enzymology, metabolism)
- Ferrous Compounds
(chemistry)
- Fever
(metabolism)
- Free Radicals
(metabolism)
- Lipid Peroxidation
- Lipopolysaccharides
- Malondialdehyde
(blood)
- Oxyhemoglobins
(metabolism, physiology)
- Pyrogens
- Rabbits
- Schiff Bases
(blood)
- Time Factors
- Vitamin E
(blood, metabolism)
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