HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Adult respiratory distress syndrome and artificial surfactant replacement in the pediatric patient.

Abstract
Adult respiratory distress syndrome (ARDS) frequently develops after near-drowning, smoke inhalation, burns, blunt trauma to chest, and overwhelming sepsis. Surfactant depletion, inactivation or destruction by the accumulation of proteinaceous material in the alveoli, and changes in the relative composition of phospholipids or protein component have been associated with ARDS. Artificial surfactant reverses these changes in experimental animals. Seven cases of ARDS have been treated on an experimental basis with artificial surfactant after approval and in accordance with ethical standards of the institution's committee on human experimentation. Informed consent was obtained from parents prior to administering artificial surfactant. We identified five cases of ARDS in retrospective analysis and used them as historical controls. Mortality between these two groups was analyzed with Fisher's exact test. One of seven (14.2%) children treated with surfactant died of overwhelming infection, and 2/5 (40%) of the historical controls died of pulmonary causes (P = 0.523). Statistically, surfactant therapy did not improve survival in patients with ARDS; however, ARDS patients receiving surfactant improved in their pulmonary dynamic compliance and had a tendency to stabilize earlier in gas exchange, allowing us to decrease ventilatory support.
AuthorsF Perez-Benavides, E Riff, C Franks
JournalPediatric emergency care (Pediatr Emerg Care) Vol. 11 Issue 3 Pg. 153-5 (Jun 1995) ISSN: 0749-5161 [Print] United States
PMID7651868 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Drug Combinations
  • Fatty Alcohols
  • Pulmonary Surfactants
  • Phosphorylcholine
  • Polyethylene Glycols
  • dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination
Topics
  • Child
  • Child, Preschool
  • Drug Combinations
  • Fatty Alcohols (therapeutic use)
  • Female
  • Humans
  • Infant
  • Male
  • Near Drowning (complications)
  • Oxygen Consumption
  • Phosphorylcholine
  • Polyethylene Glycols (therapeutic use)
  • Pulmonary Surfactants (therapeutic use)
  • Respiratory Distress Syndrome (drug therapy, etiology, mortality, physiopathology)
  • Respiratory Function Tests
  • Retrospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: