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GM-CSF clinical trials: pediatric aplastic anemia and Fanconi's anemia.

Abstract
Two clinical trials were undertaken to evaluate the effect of human recombinant granulocyte-macrophage colony stimulating factor (GM-CSF) in pancytopenic pediatric patients with aplastic anemia and Fanconi's anemia. In the aplastic anemia trial, 9 out of 12 patients had some improvement when treated with GM-CSF. In the Fanconi's anemia trial, 6 of 7 patients showed some improvement when treated with GM-CSF. For both groups, improvement in white blood cell count and absolute neutrophil count were the most common response. Side effects observed during these studies were fever, rash, urticaria, and flu-like symptoms. Nursing care of both groups focused on the effects of pancytopenia, as well as the potential adverse effects of GM-CSF. Patient education focused on teaching drug preparation and storage, subcutaneous injection, and potential side effects.
AuthorsK D Lopez, E C Guinan
JournalPediatric nursing (Pediatr Nurs) 1995 Jul-Aug Vol. 21 Issue 4 Pg. 345-9 ISSN: 0097-9805 [Print] United States
PMID7644282 (Publication Type: Clinical Trial, Clinical Trial, Phase I, Clinical Trial, Phase II, Clinical Trial, Phase III, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Granulocyte-Macrophage Colony-Stimulating Factor
Topics
  • Adolescent
  • Anemia, Aplastic (blood, nursing, therapy)
  • Child
  • Child, Preschool
  • Fanconi Anemia (blood, nursing, therapy)
  • Female
  • Granulocyte-Macrophage Colony-Stimulating Factor (therapeutic use)
  • Humans
  • Male

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