Abstract | OBJECTIVES: This study examined the angiographic characteristics, coronary risk factors and prognosis in young men and women with a history of myocardial infarction compared with that in older patients. BACKGROUND: METHODS: Of the 8,839 patients with a history of myocardial infarction in the Coronary Artery Surgery Study ( CASS), there were 294 men < or = 35 years old and 210 women < or = 45 years old. Coronary anatomy, baseline characteristics and prognosis were compared in younger and older patients. RESULTS: Young men and women more often had angiographically normal coronary arteries, nonobstructive disease < 70% stenosis and single-vessel disease than older patients (p < 0.0001). Current smoking was more frequent in young patients (p < 0.0001). Hypertension and diabetes were more frequent in both older men and women, whereas a positive family history of premature coronary disease was significantly more prevalent only in young men. The survival rate at 7 years was improved for young men compared with that in older men (84% vs. 75%, p = 0.0094) and for young women compared with that in older women (90% vs. 77%, p = 0.0004). When multivariate analysis was applied to the data, the survival advantage for young patients remained after adjustment. CONCLUSIONS: Young patients with a myocardial infarction have a favorable prognosis compared with that in older patients.
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Authors | F H Zimmerman, A Cameron, L D Fisher, G Ng |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 26
Issue 3
Pg. 654-61
(Sep 1995)
ISSN: 0735-1097 [Print] United States |
PMID | 7642855
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Adult
- Age Distribution
- Canada
(epidemiology)
- Cause of Death
- Coronary Angiography
(statistics & numerical data)
- Coronary Disease
(diagnostic imaging, epidemiology)
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging, epidemiology)
- Prognosis
- Recurrence
- Registries
(statistics & numerical data)
- Risk Factors
- Sex Distribution
- United States
(epidemiology)
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