Hyperekplexia, a cause of neonatal apnea: a case report.

Abstract

We report a case of non-familial hyperekplexia which characteristically developed apnea and feeding difficulties in the neonatal period. The abnormal startle response was evident from the second week of life onwards. The infant showed a marked improvement of the startle response and muscle hypertonia with clonazepam. Clobazam was also tried with no apparent response. A prominent long latency C response was observed on EMG examination, suggesting a possible cortical neuronal hyperexcitability origin for the abnormal startle response observed in hyperekplexia.

• Authors: J L Gherpelli, A R Nogueira Jr, E J Troster, A D Deutsch, C R Leoné, M W Brotto, A Diament, J L Ramos
• Journal: Brain & development (Brain Dev) 1995 Mar-Apr Vol. 17 Issue 2 Pg. 114-6 ISSN: 0387-7604 [Print] Netherlands
• PMID: 7625544 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Anxiety Agents
• Benzodiazepinones
• Benzodiazepines
• Clobazam
• Clonazepam

Topics

• Anti-Anxiety Agents
• Apnea (etiology)
• Benzodiazepines
• Benzodiazepinones (therapeutic use)
• Clobazam
• Clonazepam (therapeutic use)
• Electromyography
• Female
• Humans
• Infant, Newborn
• Movement Disorders (diagnosis, physiopathology)
• Reflex
• Reflex, Startle