HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Prevention of reinfarction with 100 mg or 30 mg ASS daily?].

Abstract
The prevention of heart infarction with 100 mg aspirin is common practice in Germany, in spite of the fact that it is based on only two small studies, the results of which are not generalized. Over 14 years, several experimental and clinical studies have shown that 20-30 mg aspirin/d for pharmacokinetic reason selectively inhibit the thromboxane synthesis while the endogenous prostacyclin synthesis remains intact. Prostacyclin plays an important cardioprotective role for the ischemic heart, having antiplatelet and antifibrillatory effects, potentiates the antiplatelet effect of the nitrovasodilators and nitric oxide, and increases the release of adenosine. A superior preventive action and lower side effects of 30 mg/d aspirin in direct comparison with higher doses was first proved by the Cottbus reinfarction study. The 30 mg aspirin tablet per day ought to replace the present prevention with higher doses.
AuthorsW Förster
JournalZeitschrift fur Kardiologie (Z Kardiol) Vol. 84 Issue 5 Pg. 335-43 (May 1995) ISSN: 0300-5860 [Print] Germany
Vernacular TitleReinfarktprophylaxe mit 100 mg oder 30 mg ASS täglich?
PMID7625094 (Publication Type: Comparative Study, English Abstract, Journal Article, Review)
Chemical References
  • Epoprostenol
  • Thromboxane-A Synthase
  • Aspirin
Topics
  • Animals
  • Aspirin (administration & dosage, adverse effects)
  • Dose-Response Relationship, Drug
  • Epoprostenol (blood)
  • Humans
  • Myocardial Infarction (enzymology, prevention & control)
  • Platelet Aggregation (drug effects)
  • Recurrence
  • Thromboxane-A Synthase (antagonists & inhibitors)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: