[Comparative study of ofloxacin+amoxicillin-clavulanic acid versus doxycycline+amoxicillin-clavulanic acid combination in the treatment of pelvic Chlamydia trachomatis infections].

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of ofloxacin+coamoxiclav versus doxycycline-coamoxiclav in the treatment of chlamydial pelvic infections.

DESIGN:

An open, comparative, randomised, monocentric study.

SUBJECTS:

A hundred and eighteen patients (85 endometritis and 33 salpingitis) were included. Clinical, laparoscopic and bacteriological assessments were performed before treatment. 30.4% of salpingitis were considered as severe (COGIT score > 6). 25.4% of acute pelvic infections were only caused by Chlamydia trachomatis.

TREATMENT:

A hundred and eighteen patients were treated orally with 3 week combination ofloxacin (200 mg b.i.d.) + coamoxiclav (1 g b.i.d.) (n = 60) or with a 6 week coamoxiclav (1 g b.i.d.) + doxycycline (100 mg b.i.d.) (n = 58).

RESULTS:

Oral combination ofloxacin-coamoxiclav is as effective as oral combination doxycycline+coamoxyclav with respectively 96.7% versus 96.6% and 100% versus 98.4% satisfactory clinical et bacteriological results.

• Authors: P Judlin, A Koebele, A Zaccabri, E van Walleghen, A Pavis, Y Badonnel, M Dailloux, P Landes
• Journal: Journal de gynecologie, obstetrique et biologie de la reproduction (J Gynecol Obstet Biol Reprod (Paris)) Vol. 24 Issue 3 Pg. 253-9 ( 1995) ISSN: 0368-2315 [Print] France
• Vernacular Title: Etude comparative des associations ofloxacine+amoxicilline-acide clavulanique versus doxycycline+amoxicilline-acide clavulanique dans le traitement des infections génitales hautes à Chlamydia trachomatis.
• PMID: 7622771 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Clavulanic Acids
• Amoxicillin-Potassium Clavulanate Combination
• Amoxicillin
• Ofloxacin
• Doxycycline

Topics

• Adolescent
• Adult
• Amoxicillin (therapeutic use)
• Amoxicillin-Potassium Clavulanate Combination
• Chlamydia Infections (drug therapy, microbiology)
• Chlamydia trachomatis
• Clavulanic Acids (therapeutic use)
• Doxycycline (therapeutic use)
• Drug Therapy, Combination (therapeutic use)
• Endometritis (drug therapy, microbiology)
• Female
• Humans
• Ofloxacin (therapeutic use)
• Salpingitis (drug therapy, microbiology)
• Severity of Illness Index
• Treatment Outcome