Conditioning of the secondary cytotoxic T-lymphocyte response to YC8 tumor.

Abstract

Studies from our laboratory demonstrated that conditioned resistance to the syngeneic YC8 lymphoma was established by multiple conditioned stimulus (CS)/unconditioned stimulus (US) associations. The conditioned stimulus used was exposure to the odor of camphor for 1 h and the unconditioned stimulus was an injection of DBA/2 spleen cell alloantigen that shares minor histocompatibility determinants with the YC8 lymphoma. To demonstrate a cellular basis for immune resistance to the YC8 tumor, BALB/c mice primed with DBA/2 spleen cell alloantigen were conditioned using a single trial CS/US association paradigm. Conditioned animals showed a measurable conditioned elevation of the cytotoxic T-lymphocyte (CTL) response to the YC8 tumor. Control groups in which the CS and US were not given in the proper sequence were unable to mount a conditioned response. These studies show that a secondary CTL response can be upregulated by the central nervous system (CNS).

• Authors: V K Ghanta, N S Hiramoto, S J Soong, R N Hiramoto
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 50 Issue 3 Pg. 399-403 (Mar 1995) ISSN: 0091-3057 [Print] United States
• PMID: 7617678 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Camphor

Topics

• Animals
• Camphor
• Conditioning, Classical (physiology)
• Cytotoxicity, Immunologic
• Female
• Lymphoma (immunology)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred DBA
• T-Lymphocytes (immunology)