5-HT2A serotonin receptors in the brain of rats and mice hereditarily predisposed to catalepsy.

Abstract

Specific binding of [3H]ketanserin to 5-HT2A serotonin receptor sites in the corpus striatum and frontal cortex and the effect of 5-HT2A antagonists in rats and mice hereditarily predisposed to catalepsy has been studied. Cyproheptadine inhibited the expression of inherited catalepsy in rats and mice, whereas more selective 5-HT2A antagonists, ritanserin and ketanserin, failed to affect the catalepsy. A decrease in [3H]ketanserin-specific binding site density in the striatum of cataleptic animals compared to their noncataleptic counterparts was found. It was suggested that the decrease in the density of 5-HT2A receptor binding sites in the striatum represents a result of their downregulation due to increased serotonergic neurotransmission in the striatum of cataleptic animals.

• Authors: A V Kulikov, D F Avgustinovich, V G Kolpakov, G B Maslova, N K Popova
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 50 Issue 3 Pg. 383-7 (Mar 1995) ISSN: 0091-3057 [Print] United States
• PMID: 7617676 (Publication Type: Journal Article)

Chemical References

• Receptors, Serotonin
• Serotonin Antagonists

Topics

• Animals
• Catalepsy (genetics, metabolism)
• Corpus Striatum (metabolism)
• Disease Susceptibility
• Evaluation Studies as Topic
• Frontal Lobe (metabolism)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Radioligand Assay
• Rats
• Rats, Wistar
• Receptors, Serotonin (drug effects, metabolism)
• Serotonin Antagonists (pharmacology)