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Elevated endothelin-1 plasma concentration in patients with essential hypertension.

AbstractBACKGROUND:
Endothelin-1 (ET-1) may play an important role in the development and maintenance of hypertensive states. In patients with essential hypertension, ET-1 plasma concentration increases or remains unchanged. The aim of the present study was to investigate ET-1 plasma concentration in patients with mild-to-moderate essential hypertension and its interrelationship with catecholamines, neuropeptide Y and atrial natriuretic peptide (ANP).
METHODS:
The study included 37 patients (mean age 38.2 +/- 1.6 years) with mild-to-moderate essential hypertension. The control group consisted of 21 healthy volunteers (mean age 35.6 +/- 1.4 years). ET-1, neuropeptide Y and ANP were determined by radioimmunoassay methods and catecholamine plasma concentration was determined radioenzymatically.
RESULTS:
Our study shows that plasma ET-1 and neuropeptide Y levels are elevated in patients with essential hypertension compared with a control group. No correlation was found in either of the groups between plasma ET-1 level and plasma neuropeptide Y, catecholamine or ANP concentrations.
CONCLUSION:
Our results suggest that ET-1 is relevant in the development and maintenance of elevated blood pressure.
AuthorsA Januszewicz, M Lapiński, B Symonides, E Dabrowska, A Kuch-Wocial, E Trzepla, H Ignatowska-Switalska, B Wocial, J Chodakowska, W Januszewicz
JournalJournal of cardiovascular risk (J Cardiovasc Risk) Vol. 1 Issue 1 Pg. 81-5 (Jun 1994) ISSN: 1350-6277 [Print] England
PMID7614422 (Publication Type: Journal Article)
Chemical References
  • Catecholamines
  • Endothelins
  • Neuropeptide Y
  • Atrial Natriuretic Factor
Topics
  • Adult
  • Atrial Natriuretic Factor (blood)
  • Catecholamines (blood)
  • Endothelins (blood)
  • Female
  • Humans
  • Hypertension (blood)
  • Male
  • Neuropeptide Y (blood)

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