Abstract |
Amyloidosis is a term that describes a heterogeneous group of disorders in which various tissues contain the characteristic insoluble fibrillar protein known as amyloid. A number of different forms of presentation have been described and include senile, familial or hereditary, systemic, localized, secondary and primary forms. We now report our management of a 79-year old woman who suffered from primary A-lambda-light chain amyloidosis. Amyloid changes first presented in the tissues of the tongue and floor of mouth and were seen clinically as a macroglossia. Further investigation led to a primary diagnosis of multiple myeloma IIa, as categorized by Durie and Salmon. Several cases have been reported to date describing secondary development of macroglossia due to long-term known and treated multiple myeloma. However, there has been only one report of macroglossia as a primary finding leading to the diagnosis of multiple myeloma.
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Authors | D J Arweiler, K Jahnke |
Journal | HNO
(HNO)
Vol. 43
Issue 5
Pg. 318-20
(May 1995)
ISSN: 0017-6192 [Print] Germany |
Vernacular Title | Makroglossie als Erstsymptom einer Amyloidose. |
PMID | 7607918
(Publication Type: Case Reports, English Abstract, Journal Article)
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Topics |
- Aged
- Amyloidosis
(complications, diagnosis)
- Female
- Glossectomy
- Humans
- Macroglossia
(etiology, surgery)
- Magnetic Resonance Imaging
- Mouth Floor
(pathology)
- Multiple Myeloma
(complications, diagnosis)
- Tongue
(pathology)
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