Abstract |
The aim of the present study was to investigate immunohistochemically the distribution of chromogranin A, chromogranin B, and secretogranin II in a series of 152 neuroendocrine tumours of the gastrointestinal tract. Tumour tissues from 25 argyrophil gastric carcinoids, 18 gastrin and 5 somatostatin-producing tumours, 4 ' gangliocytic paragangliomas', 49 classical argentaffin and 2 L cell appendiceal carcinoids, 27 classical ileal carcinoids, 17 rectal carcinoids, and 5 poorly differentiated neuroendocrine tumours of the stomach and rectum were immunostained with antibodies against chromogranin A, chromogranin B, and secretogranin II. Chromogranin A was the major granin expressed in gastric carcinoids and in serotonin-producing carcinoids of the appendix and the ileum. In contrast, strong chromogranin B and secretogranin II immunoreactivity was found in rectal carcinoids, in which chromogranin A was rarely expressed. Since chromogranin A is a widely used marker for neuroendocrine differentiation, it is of diagnostic importance that some gastrin-producing tumours, ' gangliocytic paragangliomas', poorly differentiated neuroendocrine carcinomas, and appendiceal L cell carcinoids completely lacked chromogranin A positivity. It is concluded that the various neuroendocrine tumours of the gastrointestinal tract show distinctly different patterns of granin expression, probably reflecting their histogenetical origin.
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Authors | A G Fahrenkamp, C Wibbeke, G Winde, D Ofner, W Böcker, R Fischer-Colbrie, K W Schmid |
Journal | Virchows Archiv : an international journal of pathology
(Virchows Arch)
Vol. 426
Issue 4
Pg. 361-7
( 1995)
ISSN: 0945-6317 [Print] Germany |
PMID | 7599788
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chromogranin A
- Chromogranins
- Proteins
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Topics |
- Chromogranin A
- Chromogranins
(analysis)
- Gastrointestinal Neoplasms
(metabolism)
- Humans
- Immunohistochemistry
- Neuroendocrine Tumors
(metabolism, pathology)
- Proteins
(analysis)
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