Abstract | BACKGROUND: METHOD: We report our experience with three OCD patients who were unimproved after a minimum of 12 weeks of treatment with the potent and selective SUI fluvoxamine, in whom we added risperidone in an open-label manner. RESULTS: All three patients showed significant improvement in their obsessive-compulsive symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) after risperidone 1 mg/day was added to ongoing fluvoxamine (250-300 mg/day). Within 4 weeks of adding risperidone, the three patients' Y-BOCS scores had decreased by 65%, 56%, and 43%, respectively. Other than mild or moderate sedation, no side effects were observed. CONCLUSION: These results suggest that risperidone addition to ongoing SUIs may be an effective treatment strategy for refractory OCD.
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Authors | C J McDougle, R L Fleischmann, C N Epperson, S Wasylink, J F Leckman, L H Price |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 56
Issue 11
Pg. 526-8
(Nov 1995)
ISSN: 0160-6689 [Print] United States |
PMID | 7592506
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Serotonin Antagonists
- Serotonin Uptake Inhibitors
- Risperidone
- Fluvoxamine
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Topics |
- Adult
- Drug Therapy, Combination
- Female
- Fluvoxamine
(therapeutic use)
- Humans
- Male
- Middle Aged
- Obsessive-Compulsive Disorder
(drug therapy, psychology)
- Risperidone
(therapeutic use)
- Serotonin Antagonists
(therapeutic use)
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Treatment Outcome
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