[Protective effects of prostacyclin on acute necrotizing pancreatitis and its renal damage in rats].

Abstract

In a rat model with acute necrotizing pancreatitis (ANP), the administration of exogenous prostacyclin (PGI2) significantly increased the pancreatic and renal blood flow, brought the level of 6-keto-PGF1 alpha to TXB2 in renal vein blood back to normal, reduced the severity of pancreatic and renal histolcagic damage, decreased the mortality, and prolonged survival time. The study showed that exogenous PGI2 can increase pancreatic blood flow in rats with ANP, help to prevent ANP, and protect from renal damage following ANP.

• Authors: S Gong, Z Ai, Y Zhou
• Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] (Zhonghua Wai Ke Za Zhi) Vol. 33 Issue 4 Pg. 197-200 (Apr 1995) ISSN: 0529-5815 [Print] China
• PMID: 7587668 (Publication Type: English Abstract, Journal Article)

Chemical References

• Epoprostenol

Topics

• Acute Disease
• Animals
• Epoprostenol (pharmacology, therapeutic use)
• Kidney (pathology)
• Male
• Necrosis
• Pancreas (blood supply)
• Pancreatitis (physiopathology, prevention & control)
• Rats
• Rats, Sprague-Dawley
• Regional Blood Flow (drug effects)
• Renal Circulation (drug effects)