Update on the use of cefotaxime for pediatric meningitis in Portugal.

Abstract

We treated 256 children who had identified bacterial meningitis with cefotaxime. Causative organisms were: Neisseria meningitidis in 108 cases, Streptococcus pneumoniae in 61, Haemophilus influenzae in 60, enteric Gram-negative bacilli in 21, and Staphylococcus spp. in six. Daily doses of cefotaxime were 150-200 mg/kg. A total of 240 patients (93.7%) were cured. In the cured patients, sterilization of cerebrospinal fluid was obtained in the first 72 h of treatment in 214 (80.0%). Cefotaxime is an effective and safe drug for the treatment of childhood bacterial meningitis.

• Authors: H Lecour, A M Miranda, J A Nogueira, C Abreu
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) 1995 May-Jun Vol. 22 Issue 1-2 Pg. 125-7 ISSN: 0732-8893 [Print] United States
• PMID: 7587025 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Cephalosporins
• Cefotaxime

Topics

• Adolescent
• Cefotaxime (administration & dosage, therapeutic use)
• Cephalosporins (administration & dosage, therapeutic use)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Infant, Newborn
• Infusions, Intravenous
• Male
• Meningitis, Bacterial (cerebrospinal fluid, drug therapy, microbiology, mortality)
• Portugal
• Survival Rate
• Treatment Outcome