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Treatment of arthritis in Lewis rats by a monoclonal antibody against alpha beta T cell receptor: differential sensitivity of Yersinia-induced arthritis versus adjuvant arthritis.

Abstract
Lewis rats experimentally infected with Yersinia enterocolitica develop sterile arthritis similar to Yersinia-associated reactive arthritis in humans. To investigate the putative role of alpha beta T cells in the pathogenesis of Yersinia-induced arthritis (YIA) rats were treated with the monoclonal antibody (mAb) R73 mAb directed against the rat alpha beta T cell receptor. In spite of reduction of alpha beta T cells in peripheral blood and in liver lesions of Yersinia-infected rats this serotherapy had no suppressive effect on YIA. Moreover, R73 mAb treatment had no influence on the number of alpha beta T cells in the inflammed synovial tissue. In contrast, R73 mAb serotherapy in Mycobaterium tuberculosis-immunized rats blocked development of adjuvant arthritis (AA) and suppressed the presence of alpha beta T cells in the synovial tissue. These results suggest fundamental differences between the immunopatho-mechanism of YIA caused by bacterial infection and AA induced by bacterial immunization and known to be T cell mediated. These data might have consequences for putative serotherapy of arthritis in humans.
AuthorsK Gaede, M Nazet, D Bosse, Hünig, J Heesemann
JournalClinical immunology and immunopathology (Clin Immunol Immunopathol) Vol. 77 Issue 3 Pg. 339-48 (Dec 1995) ISSN: 0090-1229 [Print] United States
PMID7586745 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Receptors, Antigen, T-Cell, alpha-beta
Topics
  • Animals
  • Antibodies, Monoclonal (immunology, therapeutic use)
  • Arthritis, Experimental (therapy)
  • Arthritis, Infectious (etiology, therapy)
  • Liver (pathology)
  • Male
  • Rats
  • Rats, Inbred Lew
  • Receptors, Antigen, T-Cell, alpha-beta (immunology)
  • Specific Pathogen-Free Organisms
  • Spleen (pathology)
  • Synovial Membrane (pathology)
  • T-Lymphocytes (immunology)
  • Tarsus, Animal (pathology)
  • Yersinia Infections (etiology, therapy)
  • Yersinia enterocolitica (pathogenicity)

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