A 12-month comparison of ACE inhibitor and CA antagonist therapy in mild to moderate essential hypertension--The GLANT Study. Study Group on Long-term Antihypertensive Therapy.

Abstract	Patients with mild to moderate essential hypertension were treated mainly with an ACE inhibitor (delapril, n = 980) or a Ca antagonist (n = 956) for 12 months, and the incidence of cerebrovascular and cardiovascular events as well as drug-related side effects were compared between the two groups. There were no significant differences between the clinical backgrounds of the two groups. In both groups, the blood pressure was decreased significantly from 1 month of treatment onwards, with the degree of reduction being greater in the Ca antagonist group throughout the study period (p < 0.001). Cerebrovascular or cardiovascular events occurred in 11 out of 980 patients in the delapril group and 18 out of 956 patients in the Ca antagonist group (p = NS). Cerebrovascular disease developed in 5 delapril-treated patients and 11 Ca antagonist-treated patients, and heart disease developed in 5 and 7 patients, respectively (both p = NS). Discontinuation of treatment due to side effects was significantly more common in the delapril group than in the Ca antagonist group (p < 0.001). There was no significant difference in the incidence of cerebrovascular and cardiovascular events between the two groups, and the results suggested that blood pressure reduction per se did not necessarily lead to a parallel decrease in cerebrovascular and cardiovascular complications.
Authors
Journal	Hypertension research : official journal of the Japanese Society of Hypertension (Hypertens Res) Vol. 18 Issue 3 Pg. 235-44 (Sep 1995) ISSN: 0916-9636 [Print] England
PMID	7584934 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Angiotensin-Converting Enzyme Inhibitors Calcium Channel Blockers
Topics	Adult Angiotensin-Converting Enzyme Inhibitors (adverse effects, therapeutic use) Blood Pressure (drug effects) Calcium Channel Blockers (adverse effects, therapeutic use) Cardiovascular Diseases (etiology, prevention & control) Female Follow-Up Studies Humans Hypertension (complications, drug therapy, physiopathology) Male Middle Aged Pulse (drug effects)

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