Abstract | OBJECTIVE: To compare peritonitis occurrence and outcome in a large U.K. study Multicentre Investigation of Icodextrin in Ambulatory Dialysis (MIDAS). DESIGN: SETTING: Eleven CAPD units in U.K. teaching hospital. PATIENTS: A total of 209 patients established on CAPD for at least 3 months (103 control, 106 icodextrin). Twenty-three control (C) and 22 icodextrin (I) patients experienced peritonitis during the study. INTERVENTION: Patients who had peritonitis remained on treatment (unless CAPD was withdrawn, temporarily or permanently). MAIN OUTCOME MEASURES: The main outcome measures were the rate of peritonitis and duration of CAPD treatment prestudy; the rate of peritonitis episodes and their outcome during study; the effect of peritonitis on laboratory variables, serum icodextrin metabolites, and ultrafiltration efficacy. RESULTS: Prestudy: Nine (39%) of C but 14 (64%) of I patients had suffered previous peritonitis episode(s), with overall rates of 0.58 and 0.78 episodes per patient-year, respectively. DURING STUDY: There were 31 C episodes and 35 I episodes, with overall rates of 0.76 and 0.93 per patient-year, respectively. The increase in the C and I groups was 31% and 19%, respectively. Serum osmolality and sodium levels were unaffected by peritonitis, and there was no increase in serum icodextrin metabolites during peritonitis. Overnight ultrafiltration volume during peritonitis (mean +/- SD) declined slightly from 218 +/- 354 mL to 185 +/- 299 mL (NS) in the control group, but increased in the icodextrin group from 570 +/- 146 mL to 723 +/- 218 mL (p < 0.01). CONCLUSIONS:
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Authors | R Gokal, C D Mistry, E M Peers |
Journal | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
(Perit Dial Int)
1995 Jul-Sep
Vol. 15
Issue 6
Pg. 226-30
ISSN: 0896-8608 [Print] United States |
PMID | 7578498
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Chlorides
- Dialysis Solutions
- Glucans
- Sodium
- Glucose
- Potassium
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Topics |
- Chlorides
(blood)
- Dialysis Solutions
(adverse effects, pharmacokinetics, therapeutic use)
- Glucans
(adverse effects, blood, pharmacokinetics, therapeutic use)
- Glucose
(adverse effects, pharmacokinetics, therapeutic use)
- Hemofiltration
- Humans
- Leukocyte Count
- Osmolar Concentration
- Peritoneal Dialysis, Continuous Ambulatory
(adverse effects)
- Peritoneum
(metabolism)
- Peritonitis
(blood, etiology)
- Potassium
(blood)
- Prospective Studies
- Sodium
(blood)
- Treatment Outcome
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