Optimal size matching in single lung transplantation.

Abstract

BACKGROUND:

Single lung transplantation for patients with end-stage obstructive lung disease has been highly effective in providing symptomatic relief, and it has been performed at a much increased frequency since 1983. However, there still lacks a convincing study showing the effect of size match and other preoperative variables in predicting functional outcome of patients after transplantation.

METHODS:

We evaluated 23 single lung transplantations performed for obstructive lung disease over a 34-month period. Multiple physiologic variables and size match criteria were evaluated for their contribution in determining the postoperative forced expiratory volume in 1 second at 3 months after transplantation.

RESULTS:

The size match ratio that was based on inframammary chest wall circumference was the most useful criterion to adopt, and the optimal donor/recipient size match ratio was 0.89. Furthermore, forced expiratory volume in 1 second at 3 months after transplantation could be predicted with a simple mathematical model that was based on the size match ratio and the recipient's calculated vital capacity of the transplanted hemithorax.

CONCLUSIONS:

This model could be applied in a clinical setting to maximize functional outcome of the recipients undergoing single lung transplantation.

• Authors: S J Park, J Houck, R Pifarre, H Sullivan, E Garrity, S Y Kim, J Zbilut, A Montoya
• Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transplant) 1995 Jul-Aug Vol. 14 Issue 4 Pg. 671-5 ISSN: 1053-2498 [Print] United States
• PMID: 7578174 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Female
• Follow-Up Studies
• Forced Expiratory Volume (physiology)
• Humans
• Lung (physiopathology)
• Lung Diseases, Obstructive (physiopathology, surgery)
• Lung Transplantation (physiology)
• Male
• Middle Aged
• Models, Theoretical
• Organ Size (physiology)
• Postoperative Complications (physiopathology)
• Pulmonary Wedge Pressure (physiology)
• Tissue Donors
• Vital Capacity (physiology)